Structure–function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation

Transformation promotes genome plasticity in bacteria via RecA-driven homologous recombination. In the Gram-positive human pathogen Streptococcus pneumoniae, the transformasome a multiprotein complex, internalizes, protects, and processes transforming DNA to generate chromosomal recombinants. Double...

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Main Authors: Quevillon-Cheruel, Sophie, Campo, Nathalie, Mirouze, Nicolas, Mortier-Barrière, Isabelle, Brooks, Mark A., Boudes, Marion, Durand, Dominique, Soulet, Anne-Lise, Lisboa, Johnny, Noirot, Philippe, Martin, Bernard, van Tilbeurgh, Herman, Noirot-Gros, Marie-Françoise, Claverys, Jean-Pierre, Polard, Patrice
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443122/
https://ncbi.nlm.nih.gov/pubmed/22904190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205638109
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