A Novel Hydrogen Sulfide-releasing N-Methyl-d-Aspartate Receptor Antagonist Prevents Ischemic Neuronal Death

Physiological levels of H(2)S exert neuroprotective effects, whereas high concentrations of H(2)S may cause neurotoxicity in part via activation of NMDAR. To characterize the neuroprotective effects of combination of exogenous H(2)S and NMDAR antagonism, we synthesized a novel H(2)S-releasing NMDAR...

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Autores principales: Marutani, Eizo, Kosugi, Shizuko, Tokuda, Kentaro, Khatri, Ashok, Nguyen, Rebecca, Atochin, Dmitriy N., Kida, Kotaro, Van Leyen, Klaus, Arai, Ken, Ichinose, Fumito
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442543/
https://ncbi.nlm.nih.gov/pubmed/22815476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374124
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