Catalytic Convergence of Manganese and Iron Lipoxygenases by Replacement of a Single Amino Acid

Lipoxygenases (LOXs) contain a hydrophobic substrate channel with the conserved Gly/Ala determinant of regio- and stereospecificity and a conserved Leu residue near the catalytic non-heme iron. Our goal was to study the importance of this region (Gly(332), Leu(336), and Phe(337)) of a lipoxygenase w...

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Detaylı Bibliyografya
Asıl Yazarlar: Wennman, Anneli, Jernerén, Fredrik, Hamberg, Mats, Oliw, Ernst H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Lipids
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442510/
https://ncbi.nlm.nih.gov/pubmed/22822060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364331
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