Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

Using specific inhibitors, kinase-negative mutants, and small interfering RNA against protein kinase Cα (PKCα) or PKCβI, we find that PKCβI positively regulates degranulation in rat basophilic leukemia–2H3 cells, whereas PKCα negatively regulates degranulation. Mass spectrometric and mutagenic analy...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Sakuma, Megumi, Shirai, Yasuhito, Yoshino, Ken-ichi, Kuramasu, Maho, Nakamura, Tomofumi, Yanagita, Toshihiko, Mizuno, Kensaku, Hide, Izumi, Nakata, Yoshihiro, Saito, Naoaki
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2012
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442417/
https://ncbi.nlm.nih.gov/pubmed/22855535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-01-0053
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki