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Neuralized1 Activates CPEB3: A Novel Function of Ubiquitination in Synaptic Plasticity and Memory Storage

The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local protein synthesis, is the mouse homologue of ApCPEB, a functional prion protein in Aplysia. Here, we provide evidence that CPEB3 is activated by Neuralized1, an E3 ubiquitin ligase. In hippocampal cultures, CPEB3...

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Detalhes bibliográficos
Main Authors: Pavlopoulos, Elias, Trifilieff, Pierre, Chevaleyre, Vivien, Fioriti, Luana, Zairis, Sakellarios, Pagano, Andrew, Malleret, Gaël, Kandel, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442370/
https://ncbi.nlm.nih.gov/pubmed/22153079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.056
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