Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton

Neurofibromin regulates cell motility via three distinct GTPase pathways acting through two different domains, the Ras GTPase-activating protein-related domain (GRD) and the pre-GRD domain. First, the GRD domain inhibits Ras-dependent changes in cell motility through the mitogen activated protein ca...

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Main Authors: Mashiach-Farkash, Efrat, Rak, Roni, Elad-Sfadia, Galit, Haklai, Roni, Carmeli, Shmuel, Kloog, Yoel, Wolfson, Haim J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2012
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442289/
https://ncbi.nlm.nih.gov/pubmed/22776759
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