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Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats

The orexin/hypocretin system has been implicated in multiple phases of drug addiction. Acute orexin receptor blockade with the orexin-1 receptor (OX1R) antagonist, SB-334867, has been found to reduce cocaine seeking after cocaine self-administration. As repeated drug dosing can have differential eff...

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Detalhes bibliográficos
Main Authors: Zhou, Luyi, Smith, Rachel J., Do, Phong H., Aston-Jones, Gary, See, Ronald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442258/
https://ncbi.nlm.nih.gov/pubmed/22971541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.07.044
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