Lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue

Phylogeny shows that CD4 T cell memory and lymph nodes (LNs) co-evolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR) γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian LNs. Here, we show that while primary CD4 T cell expansion is normal in...

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Auteurs principaux: Withers, David R., Gaspal, Fabrina M., Mackley, Emma C., Marriott, Clare L., Ross, Ewan A., Desanti, Guillaume E., Roberts, Natalie A., White, Andrea J., Flores-Langarica, Adriana, McConnell, Fiona M., Anderson, Graham, Lane, Peter J.L.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442242/
https://ncbi.nlm.nih.gov/pubmed/22855716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201639
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