Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow

We describe a mathematical/computational model for thrombin concentration gradients generated by procoagulant circulating tumor cells (CTCs) in flow. We examine how CTCs enhance blood coagulation as they diffuse tissue factor-dependent coagulation enzymes in a flow environment with vessel walls. Con...

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Autori principali: Lee, Angela M., Tormoen, Garth W., Kanso, Eva, McCarty, Owen J. T., Newton, Paul K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Research Foundation 2012
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442195/
https://ncbi.nlm.nih.gov/pubmed/23050240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00108
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