Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents

AIM: The study aims were to characterize risperidone and (±)-9-hydroxyrisperidone pharmacokinetic variability in children and adolescents and to evaluate covariate effects on pharmacokinetic parameters. METHODS: Steady-state samples were drawn at pre-dose, 1, 2, 4, and 7 hours post-dose; CYP2D6 geno...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sherwin, Catherine M. T., Saldaña, Shannon N., Bies, Robert R., Aman, Michael G., Vinks, Alexander A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442132/
https://ncbi.nlm.nih.gov/pubmed/22929407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318261c240
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