Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

BACKGROUND: It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise the use of iHDACs in combination with other cytotoxic agents that are substrates of P-glycoprotein (Pgp). It has a...

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Autori principali: Balaguer, Trinidad Mata, Gómez-Martínez, Angeles, García-Morales, Pilar, Lacueva, Javier, Calpena, Rafael, Reverte, Lourdes Rocamora, Riquelme, Natividad Lopez, Martinez-Lacaci, Isabel, Ferragut, José A, Saceda, Miguel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441908/
https://ncbi.nlm.nih.gov/pubmed/22846052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-13-25
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