Synthetic genistein derivatives as modulators of glycosaminoglycan storage

BACKGROUND: Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain lysosomal hydrolases. Substrate reduction therapy (SRT) has been proposed as one of potential treatment procedures of MPS. Impo...

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Hauptverfasser: Kloska, Anna, Narajczyk, Magdalena, Jakóbkiewicz-Banecka, Joanna, Grynkiewicz, Grzegorz, Szeja, Wiesław, Gabig-Cimińska, Magdalena, Węgrzyn, Grzegorz
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441846/
https://ncbi.nlm.nih.gov/pubmed/22846663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-153
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