Synthetic genistein derivatives as modulators of glycosaminoglycan storage

BACKGROUND: Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain lysosomal hydrolases. Substrate reduction therapy (SRT) has been proposed as one of potential treatment procedures of MPS. Impo...

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Detalhes bibliográficos
Main Authors: Kloska, Anna, Narajczyk, Magdalena, Jakóbkiewicz-Banecka, Joanna, Grynkiewicz, Grzegorz, Szeja, Wiesław, Gabig-Cimińska, Magdalena, Węgrzyn, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441846/
https://ncbi.nlm.nih.gov/pubmed/22846663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-153
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