Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff

Cleavage of eukaryotic translation initiation factor 4GI (eIF4GI) by viral 2A protease (2Apro) has been proposed to cause severe translation inhibition in poliovirus-infected cells. However, infections containing 1 mM guanidine-HCl result in eIF4GI cleavage but only partial translation shutoff, indi...

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Detalhes bibliográficos
Main Authors: Kuyumcu-Martinez, N. Muge, Van Eden, Marc E., Younan, Patrick, Lloyd, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344173/
https://ncbi.nlm.nih.gov/pubmed/14749392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1779-1790.2004
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