Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency

BACKGROUND: Hematopoietic stem cell (HSC) gene therapy has cured immunodeficiencies including X-linked severe combined immunodeficiency (SCID-X1) and adenine deaminase deficiency (ADA). For these immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-modified...

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Main Authors: Trobridge, Grant D., Beard, Brian C., Wu, Robert A., Ironside, Christina, Malik, Punam, Kiem, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441638/
https://ncbi.nlm.nih.gov/pubmed/23028826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045173
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