An Anilinoquinazoline Derivative Inhibits Tumor Growth through Interaction with hCAP-G2, a Subunit of Condensin II

We screened 46 novel anilinoquinazoline derivatives for activity to inhibit proliferation of a panel of human cancer cell lines. Among them, Q15 showed potent in vitro growth-inhibitory activity towards cancer cell lines derived from colorectal cancer, lung cancer and multiple myeloma. It also showe...

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Bibliographic Details
Main Authors: Shiheido, Hirokazu, Naito, Yuhei, Kimura, Hironobu, Genma, Hiroaki, Takashima, Hideaki, Tokunaga, Mayuko, Ono, Takao, Hirano, Tatsuya, Du, Wenlin, Yamada, Taketo, Doi, Nobuhide, Iijima, Shiro, Hattori, Yutaka, Yanagawa, Hiroshi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441599/
https://ncbi.nlm.nih.gov/pubmed/23028663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044889
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