The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice

BACKGROUND & AIMS: T helper (Th) 17 cells produce the effector cytokine interleukin (IL)-17, along with IL-22, which stimulates colonic epithelial cells to produce a membrane-bound mucin, Muc1. Muc1 is a component of the colonic mucus, which functions as a lubricant and a physiologic barrier bet...

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Main Authors: Nishida, Atsushi, Lau, Cindy W., Zhang, Mei, Andoh, Akira, Shi, Hai Ning, Mizoguchi, Emiko, Mizoguchi, Atsushi
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441148/
https://ncbi.nlm.nih.gov/pubmed/22202458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.12.036
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