Phase II Trial of Neoadjuvant Exemestane in Combination With Celecoxib in Postmenopausal Women Who Have Breast Cancer

PURPOSE: Within breast tissue, aromatase expression and activity is increased by prostaglandin E2, providing a rationale for combining the COX-2 inhibitor celecoxib with an aromatase inhibitor. To evaluate the effect of these drugs on aromatase and other biomarkers, a phase II trial of neoadjuvant e...

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Main Authors: Lustberg, Maryam B., Povoski, Stephen P., Zhao, Weiqiang, Ziegler, Rebecca M., Sugimoto, Yasuro, Ruppert, Amy S., Lehman, Amy M., Shiels, Donna R., Mrozek, Ewa, Ramaswamy, Bhuvaneswari, Layman, Rachel M., Brueggemeier, Robert W., Shapiro, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440773/
https://ncbi.nlm.nih.gov/pubmed/21729671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clbc.2011.03.022
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