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Short-term information processing, long-term responses: Insights by mathematical modeling of signal transduction: Early activation dynamics of key signaling mediators can be predictive for cell fate decisions

How do cells interpret information from their environment and translate it into specific cell fate decisions? We propose that cell fate is already encoded in early signaling events and thus can be predicted from defined signal properties. Specifically, we hypothesize that the time integral of activa...

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書目詳細資料
Main Authors: Schneider, Annette, Klingmüller, Ursula, Schilling, Marcel
格式: Artigo
語言:Inglês
出版: WILEY-VCH Verlag 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440590/
https://ncbi.nlm.nih.gov/pubmed/22528856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201100172
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