PROENKEPHALIN MEDIATES THE ENDURING EFFECTS OF ADOLESCENT CANNABIS EXPOSURE ASSOCIATED WITH ADULT OPIATE VULNERABILITY

BACKGROUND: Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NA...

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Detalhes bibliográficos
Main Authors: Tomasiewicz, Hilarie C., Jacobs, Michelle M., Wilkinson, Matthew B., Wilson, Steven P., Nestler, Eric J., Hurd, Yasmin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440551/
https://ncbi.nlm.nih.gov/pubmed/22683090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.04.026
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