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Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio-Temporal Interplay of ERK Activation

It is well established that EGFR signals from both the plasma membrane (PM) and endosome (EN). However, very little is known about whether and how the EGFR signals at the PM and EN to differentially regulate various signaling pathways and the physiological outcomes. In this communication, we establi...

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Detalhes bibliográficos
Main Authors: Wu, Peng, Wee, Ping, Jiang, Jennifer, Chen, Xinmei, Wang, Zhixiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440385/
https://ncbi.nlm.nih.gov/pubmed/22984397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041354
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