Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma

BACKGROUND: Medulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well established for their roles in tumor progression. The...

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Main Authors: Kotipatruni, Ramaprasada Rao, Nalla, Arun Kumar, Asuthkar, Swapna, Gondi, Christopher S., Dinh, Dzung H., Rao, Jasti S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440337/
https://ncbi.nlm.nih.gov/pubmed/22984561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044798
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