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Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites

Transcripts of the human tumor susceptibility gene 101 (TSG101) are aberrantly spliced in many cancers. A major aberrant splicing event on the TSG101 pre-mRNA involves joining of distant alternative 5′ and 3′ splice sites within exon 2 and exon 9, respectively, resulting in the extensive elimination...

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Hlavní autoři: Kameyama, Toshiki, Suzuki, Hitoshi, Mayeda, Akila
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439910/
https://ncbi.nlm.nih.gov/pubmed/22675076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks520
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