Bulged DNA substrates for identifying poxvirus resolvase inhibitors

Resolvase enzymes that cleave DNA four-way (Holliday) junctions are required for poxvirus replication, but clinically useful inhibitors have not been developed. Here, we report an assay for resolvase cleavage activity based on fluorescence polarization (FP) for high-throughput screening and mechanis...

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Autors principals: Culyba, Matthew, Hwang, Young, Attar, Sana, Madrid, Peter B., Bupp, James, Huryn, Donna, Sanchez, Luis, Grobler, Jay, Miller, Michael D., Bushman, Frederic D.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439875/
https://ncbi.nlm.nih.gov/pubmed/22581770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks325
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