Bulged DNA substrates for identifying poxvirus resolvase inhibitors

Resolvase enzymes that cleave DNA four-way (Holliday) junctions are required for poxvirus replication, but clinically useful inhibitors have not been developed. Here, we report an assay for resolvase cleavage activity based on fluorescence polarization (FP) for high-throughput screening and mechanis...

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Main Authors: Culyba, Matthew, Hwang, Young, Attar, Sana, Madrid, Peter B., Bupp, James, Huryn, Donna, Sanchez, Luis, Grobler, Jay, Miller, Michael D., Bushman, Frederic D.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
主題:
Methods Online
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439875/
https://ncbi.nlm.nih.gov/pubmed/22581770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks325
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