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Investigating drug repositioning opportunities in FDA drug labels through topic modeling

BACKGROUND: Drug repositioning offers an opportunity to revitalize the slowing drug discovery pipeline by finding new uses for currently existing drugs. Our hypothesis is that drugs sharing similar side effect profiles are likely to be effective for the same disease, and thus repositioning opportuni...

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Detalhes bibliográficos
Main Authors: Bisgin, Halil, Liu, Zhichao, Kelly, Reagan, Fang, Hong, Xu, Xiaowei, Tong, Weida
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439728/
https://ncbi.nlm.nih.gov/pubmed/23046522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-S15-S6
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