Human Complement Receptor 2 (CR2/CD21) as a Receptor for DNA: Implications for its Roles in the Immune Response and the Pathogenesis of Systemic Lupus Erythematosus (SLE)

Human CR2 is a B cell membrane glycoprotein that plays a central role in autoimmunity. Systemic lupus erythematosus (SLE) patients show reduced CR2 levels, and complete deficiency of CR2 and CR1 promotes the development of anti-DNA antibodies in mouse models of SLE. Here we show that multiple forms...

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Bibliografiska uppgifter
Huvudupphovsmän: Asokan, Rengasamy, Banda, Nirmal K., Szakonyi, Gerda, Chen, Xiaojiang S., Holers, V. Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439536/
https://ncbi.nlm.nih.gov/pubmed/22885687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.07.002
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