Frank-ter Haar Syndrome Protein Tks4 Regulates Epidermal Growth Factor-dependent Cell Migration

Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of podosome formation. Here, we report a novel role for Tks4 in the EGF signaling pathway. In EGF-...

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Hlavní autoři: Bögel, Gábor, Gujdár, Annamária, Geiszt, Miklós, Lányi, Árpád, Fekete, Anna, Sipeki, Szabolcs, Downward, Julian, Buday, László
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438961/
https://ncbi.nlm.nih.gov/pubmed/22829589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324897
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