Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis by its ability to synthesize fructose-2,6-bisphosphate, a potent allosteric activator of 6-phosphofructo-1-kinase. Being a substrate of the E3 ubiquitin ligase anaphase-promoting complex-Cdh1 (APC(Cdh...

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Autores principales: Rodriguez-Rodriguez, P, Fernandez, E, Almeida, A, Bolaños, J P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438489/
https://ncbi.nlm.nih.gov/pubmed/22421967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.33
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