The β(3)-Integrin Ligand of Borrelia burgdorferi is Critical for Infection of Mice but not Ticks

P66 is a Borrelia burgdorferi surface protein with β(3) integrin binding and channel forming activities. In this study, the role of P66 in mammalian and tick infection was examined. B. burgdorferiΔp66 strains were not infectious in wild-type, TLR2(−/−) or MyD88(−/−) deficient mice. Strains with p66...

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Main Authors: Ristow, Laura C., Miller, Halli E., Padmore, Lavinia J., Chettri, Rekha, Salzman, Nita, Caimano, Melissa J., Rosa, Patricia A., Coburn, Jenifer
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438374/
https://ncbi.nlm.nih.gov/pubmed/22758390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2012.08160.x
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