Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice

BACKGROUND: Levamisole, an imidazo(2,1-b)thiazole derivative, has been reported to be a potential antitumor agent. In the present study, we have investigated the mechanism of action of one of the recently identified analogues, 4a (2-benzyl-6-(4′-fluorophenyl)-5-thiocyanato-imidazo[2,1-b][1], [3], [4...

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Detalhes bibliográficos
Main Authors: Hegde, Mahesh, Karki, Subhas S., Thomas, Elizabeth, Kumar, Sujeet, Panjamurthy, Kuppusamy, Ranganatha, Somasagara R., Rangappa, Kanchugarakoppal S., Choudhary, Bibha, Raghavan, Sathees C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438185/
https://ncbi.nlm.nih.gov/pubmed/22970136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043632
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