Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1–CBFβ interaction

Core binding factor (CBF) leukemias, those with translocations or inversions that affect transcription factor genes RUNX1 or CBFB, account for ∼24% of adult acute myeloid leukemia (AML) and 25% of pediatric acute lymphocytic leukemia (ALL). Current treatments for CBF leukemias are associated with si...

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Main Authors: Cunningham, Lea, Finckbeiner, Steven, Hyde, R. Katherine, Southall, Noel, Marugan, Juan, Yedavalli, Venkat R. K., Dehdashti, Seameen Jean, Reinhold, William C., Alemu, Lemlem, Zhao, Ling, Yeh, Jing-Ruey Joanna, Sood, Raman, Pommier, Yves, Austin, Christopher P., Jeang, Kuan-Teh, Zheng, Wei, Liu, Paul
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437880/
https://ncbi.nlm.nih.gov/pubmed/22912405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200037109
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