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Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4(+) T-cell migration and suppression of effector function

After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mason, Gavin M., Poole, Emma, Sissons, J. G. Patrick, Wills, Mark R., Sinclair, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437838/
https://ncbi.nlm.nih.gov/pubmed/22826250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204836109
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