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Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4(+) T-cell migration and suppression of effector function

After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects...

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Main Authors: Mason, Gavin M., Poole, Emma, Sissons, J. G. Patrick, Wills, Mark R., Sinclair, John H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437838/
https://ncbi.nlm.nih.gov/pubmed/22826250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204836109
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