Potent, Selective, and Orally Available Benzoisothiazolone Phosphomannose Isomerase Inhibitors as Probes for Congenital Disorder of Glycosylation Ia

We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme which converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P), and more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, d...

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Autori principali: Dahl, Russell, Bravo, Yalda, Sharma, Vandana, Ichikawa, Mie, Dhanya, Raveendra-Panickar, Hedrick, Michael, Brown, Brock, Rascon, Justin, Vicchiarelli, Michael, Mangravita-Novo, Arianna, Yang, Li, Stonich, Derek, Su, Ying, Smith, Layton H., Sergienko, Eduard, Freeze, Hudson H., Cosford, Nicholas D. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437750/
https://ncbi.nlm.nih.gov/pubmed/21539312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101401a
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