Flow cytometric immunobead assay for fast and easy detection of PML–RARA fusion proteins for the diagnosis of acute promyelocytic leukemia

The PML–RARA fusion protein is found in approximately 97% of patients with acute promyelocytic leukemia (APL). APL can be associated with life-threatening bleeding complications when undiagnosed and not treated expeditiously. The PML–RARA fusion protein arrests maturation of myeloid cells at the pro...

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Main Authors: Dekking, E H A, van der Velden, V H J, Varro, R, Wai, H, Böttcher, S, Kneba, M, Sonneveld, E, Koning, A, Boeckx, N, Van Poecke, N, Lucio, P, Mendonça, A, Sedek, L, Szczepański, T, Kalina, T, Kanderová, V, Hoogeveen, P, Flores-Montero, J, Chillón, M C, Orfao, A, Almeida, J, Evans, P, Cullen, M, Noordijk, A L, Vermeulen, P M, de Man, M T, Dixon, E P, Comans-Bitter, W M, van Dongen, J J M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437408/
https://ncbi.nlm.nih.gov/pubmed/22948489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.125
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