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Activation of AMP-activated protein kinase alleviates high glucose-induced dysfunction of brain microvascular endothelial cell tight junction dynamics

BACKGROUND: The blood-brain-barrier, formed by specialized brain endothelial cells that are interconnected by tight junctions, strictly regulates paracellular permeability to maintain an optimal extracellular environment for brain homeostasis. Diabetes is known to compromise the blood-brain-barrier...

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Bibliografiske detaljer
Main Authors: Liu, Chao, Wu, Jiliang, Zou, Ming-hui
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437014/
https://ncbi.nlm.nih.gov/pubmed/22796592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.07.003
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