n-Butylidenephthalide (BP) Maintains Stem Cell Pluripotency by Activating Jak2/Stat3 Pathway and Increases the Efficiency of iPS Cells Generation

In 2006, induced pluripotent stem (iPS) cells were generated from somatic cells by introducing Oct4, Sox2, c-Myc and Klf4. The original process was inefficient; maintaining the pluripotency of embryonic stem (ES) and iPS cell cultures required an expensive reagent–leukemia induced factor (LIF). Our...

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Main Authors: Liu, Shih-Ping, Harn, Horng-Jyh, Chien, Ying-Jiun, Chang, Cheng-Hsuan, Hsu, Chien-Yu, Fu, Ru-Huei, Huang, Yu-Chuen, Chen, Shih-Yin, Shyu, Woei-Cherng, Lin, Shinn-Zong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436873/
https://ncbi.nlm.nih.gov/pubmed/22970157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044024
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