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Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase
Histamine is an important chemical mediator for a wide variety of physiological reactions. l-Histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. In this study, we determined the crystal structure of hum...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436558/ https://ncbi.nlm.nih.gov/pubmed/22767596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.381897 |
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