Multifaceted Mechanisms of HIV-1 Entry Inhibition by Human α-Defensin

The human neutrophil peptide 1 (HNP-1) is known to block the human immunodeficiency virus type 1 (HIV-1) infection, but the mechanism of inhibition is poorly understood. We examined the effect of HNP-1 on HIV-1 entry and fusion and found that, surprisingly, this α-defensin inhibited multiple steps o...

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Detalhes bibliográficos
Main Authors: Demirkhanyan, Lusine H., Marin, Mariana, Padilla-Parra, Sergi, Zhan, Changyou, Miyauchi, Kosuke, Jean-Baptiste, Maikha, Novitskiy, Gennadiy, Lu, Wuyuan, Melikyan, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436536/
https://ncbi.nlm.nih.gov/pubmed/22733823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375949
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