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Structural Basis for the Reaction Mechanism of S-Carbamoylation of HypE by HypF in the Maturation of [NiFe]-Hydrogenases

As a remarkable structural feature of hydrogenase active sites, [NiFe]-hydrogenases harbor one carbonyl and two cyano ligands, where HypE and HypF are involved in the biosynthesis of the nitrile group as a precursor of the cyano groups. HypF catalyzes S-carbamoylation of the C-terminal cysteine of H...

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Detalles Bibliográficos
Main Authors: Shomura, Yasuhito, Higuchi, Yoshiki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436534/
https://ncbi.nlm.nih.gov/pubmed/22740694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.387134
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