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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed. Here, we show that treatment of chronically infected chimpanzees with a locked nucleic acid (L...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436126/ https://ncbi.nlm.nih.gov/pubmed/19965718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178178 |
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