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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed. Here, we show that treatment of chronically infected chimpanzees with a locked nucleic acid (L...

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Библиографические подробности
Главные авторы: Lanford, Robert E., Hildebrandt-Eriksen, Elisabeth S., Petri, Andreas, Persson, Robert, Lindow, Morten, Munk, Martin E., Kauppinen, Sakari, Ørum, Henrik
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436126/
https://ncbi.nlm.nih.gov/pubmed/19965718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178178
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