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Wild Type TDP-43 Induces Neuro-Inflammation and Alters APP Metabolism in Lentiviral Gene Transfer Models
The transactivation DNA-binding protein (TDP-43) pathology is associated with Fronto-Temporal Lobar Dementia (FTLD) with ubiquitinated inclusions and some cases of Alzheimer's disease (AD). Proteolytic fragments of β-amyloid precursor protein (βAPP) are detected in AD as well as the cerebrospin...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434705/ https://ncbi.nlm.nih.gov/pubmed/22402344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.02.011 |
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