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MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts

Fas expression is inversely correlated with the metastatic potential of osteosarcoma (OS) cells to the lungs. Fas(+) cells are rapidly eliminated when they enter the lungs via their interaction with constitutive Fas ligand (FasL) on the lung epithelium, whereas Fas(−) OS cells escape this FasL-induc...

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Autors principals: Rao-Bindal, K, Zhou, Z, Kleinerman, E S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434650/
https://ncbi.nlm.nih.gov/pubmed/22875006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.101
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