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Transient Neonatal Diabetes Mellitus Gene Zac1 Impairs Insulin Secretion in Mice through Rasgrf1

The biallelic expression of the imprinted gene ZAC1/PLAGL1 underlies ∼60% of all cases of transient neonatal diabetes mellitus (TNDM) that present with low perinatal insulin secretion. Molecular targets of ZAC1 misexpression in pancreatic β cells are unknown. Here, we identified the guanine nucleoti...

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Bibliographic Details
Main Authors: Hoffmann, Anke, Spengler, Dietmar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434484/
https://ncbi.nlm.nih.gov/pubmed/22547676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06637-11
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