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Toll-Like Receptor 4 and High-Mobility Group Box 1 Are Critical Mediators of Tissue Injury and Survival in a Mouse Model for Heatstroke

The molecular mechanisms that initiate the inflammatory response in heatstroke and their relation with tissue injury and lethality are not fully elucidated. We examined whether endogenous ligands released by damaged/stressed cells such as high-mobility group box 1 (HMGB1) signaling through Toll-like...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dehbi, Mohammed, Uzzaman, Taher, Baturcam, Engin, Eldali, Abdelmoneim, Ventura, Wilhelmina, Bouchama, Abderrezak
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2012
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433483/
https://ncbi.nlm.nih.gov/pubmed/22962600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044100
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