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The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase

Understanding the effects of organic co-solvents on protein structure and function is pivotal to engineering enzymes for biotransformation in non-aqueous solvents. The effects of DMSO on the catalytic activity of cytochrome P450 BM3 have previously been investigated and the importance of Phe87 in it...

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Bibliografiske detaljer
Main Authors: Kuper, Jochen, Tee, Kang Lan, Wilmanns, Matthias, Roccatano, Danilo, Schwaneberg, Ulrich, Wong, Tuck Seng
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433188/
https://ncbi.nlm.nih.gov/pubmed/22949185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112031570
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