BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9

Mutation in the BRCA1 gene is associated with increased risk for hereditary breast and ovarian cancers. In sporadic ovarian tumors, BRCA1 dysfunction is thought to be common. BRCA1 is a nuclear-cytoplasm shuttling protein. Our group has previously reported that BRCA1 proteins, unlike K109R and cance...

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Hlavní autoři: Qin, Yunlong, Xu, Jingyao, Aysola, Kartik, Oprea, Gabriela, Reddy, Avinash, Matthews, Roland, Okoli, Joel, Cantor, Alan, Grizzle, William E, Partridge, Edward E, Reddy, E Shyam P, Landen, Charles, Rao, Veena N
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433105/
https://ncbi.nlm.nih.gov/pubmed/22957306
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