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Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited
Unlimited ultrasensitivity in a kinase/phosphatase “futile cycle” has been a paradigmatic example of collective behaviour in multi-enzyme systems. However, its analysis has relied on the Michaelis-Menten reaction mechanism, which remains widely used despite a century of new knowledge. Modifying and...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432734/ https://ncbi.nlm.nih.gov/pubmed/22828569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2012.07.012 |
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