Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome

The 22q11.2 microdeletion is one of the highest genetic risk factors for schizophrenia. It is not well understood which interactions of deleted genes in 22q11.2 regions are responsible for the pathogenesis of schizophrenia, but catechol-O-methytransferase (COMT) is among the candidates. Df1/+ mice a...

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Detalhes bibliográficos
Main Authors: Kimoto, S, Muraki, K, Toritsuka, M, Mugikura, S, Kajiwara, K, Kishimoto, T, Illingworth, E, Tanigaki, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432186/
https://ncbi.nlm.nih.gov/pubmed/22872161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2012.70
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