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Proline dehydrogenase is essential for proline protection against hydrogen peroxide induced cell death

Proline metabolism has an underlying role in apoptotic signaling that impacts tumorigenesis. Proline is oxidized to glutamate in the mitochondria with the rate limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53 leading to increased proline oxidation, react...

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Bibliografski detalji
Glavni autori: Natarajan, Sathish Kumar, Zhu, Weidong, Liang, Xinwen, Zhang, Lu, Demers, Andrew J., Zimmerman, Matthew C., Simpson, Melanie A., Becker, Donald F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432146/
https://ncbi.nlm.nih.gov/pubmed/22796327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.07.002
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