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Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia
Mutations in the gene encoding connexin-43 (Cx43) cause the human development disorder known as oculodentodigital dysplasia (ODDD). In this study, ODDD-linked Cx43 N-terminal mutants formed nonfunctional gap junction–like plaques and exhibited dominant-negative effects on the coupling conductance of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431933/ https://ncbi.nlm.nih.gov/pubmed/22809623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-02-0128 |
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