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Effects of a Buried Cysteine-To-Serine Mutation on Yeast Triosephosphate Isomerase Structure and Stability

All the members of the triosephosphate isomerase (TIM) family possess a cystein residue (Cys126) located near the catalytically essential Glu165. The evolutionarily conserved Cys126, however, does not seem to play a significant role in the catalytic activity. On the other hand, substitution of this...

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Bibliographische Detailangaben
Hauptverfasser: Hernández-Santoyo, Alejandra, Domínguez-Ramírez, Lenin, Reyes-López, César A., González-Mondragón, Edith, Hernández-Arana, Andrés, Rodríguez-Romero, Adela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Diversity Preservation International (MDPI) 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431843/
https://ncbi.nlm.nih.gov/pubmed/22949845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms130810010
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